Determining the Correct Pathophysiology of CRPS

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Understanding the molecular physiological profile of CRPS requires study of CRPS tissue. Most studies on the pathophysiology of CRPS are based on core biopsy of tissue samples taken from living patients, postmortem exam and from post amputation studies. CRPS patient samples are shown to possess a unique tissue type and evidence of injury to autonomic nerve fibers and tissue in both type 1 and type 2 CRPS patients. CURE CRPS Foundation is interested in studying these tissue types and reviewing science on various tissues including molecular study of Glia, Neurons, muscular, bone, Blood vessels, micro capillaries, lymphatic vessels as well as examine the functional health of the neuromuscular junctions including vasomotor reactivity. Scientists have found essentially that CRPS patient tissues in flair zones have undergone physical changes associated with epigenetic cellular changes. CRPS impacted cells have been specialized to upregulate signaling along the region which will impact the function of muscle, absorption of nutrients to cells, oxygenation, bone resorption, tissue repair. (Change of function mutations). The tissue of CRPS impacted regions is known to be effectively sponge-like in nature where capillary fill rates are unique, where blood pressure is unique, vessels are more porous, where muscles fiber shape, tone and temperature is unique and activates independant of CNS action. CRPS cells generally have more voltage gated sodium channels and g-coupled receptors including NMDA receptors. CRPS impacted regions of the body therefore are physically unique and there is evidence of epigenetic change which unfortunately can cause upstream DNA customization (Spread of CRPS / centralization). REQUEST FOR STUDY A RFP has been published requesting study of Pathophysiology and genetic profile of CRPS tissues. RESEARCH1.) NIH review of CRPS Factsheet. NINDS division of NIH. 2019.